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Use of red blood cell fatty-acid profiles as biomarkers in cardiac disease.
MedLine Citation:
PMID:  20477493     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The Omega-3 Index is defined as the percentage of eicosapentaenoic acid plus docosahexaenoic acid in red blood cell fatty acids, assessed by a standardized methodology. Better than fatty-acid compositions in other compartments, the Omega-3 Index represents a person's status in eicosapentaenoic acid plus docosahexaenoic acid. An Omega-3 Index less than 4% is associated with a tenfold risk for sudden cardiac death in comparison to an Omega-3 Index greater than 8%. Mechanisms of action are plausible and large-scale intervention studies in humans support causality. A low Omega-3 Index may also be a risk factor for coronary artery disease and for complications of congestive heart failure. Ongoing research will define the value of the Omega-3 Index as a risk factor and treatment parameter more precisely.
Authors:
Clemens von Schacky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  3     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  -    
Affiliation:
Preventive Cardiology, Medizinische Klinik & Poliklinik Innenstadt, Ziemssenstr 1, D-80336 M?nchen, Germany and, Omegametrix, Am Klopferspitz19, D-82152 Martinsried, Germany. clemens.vonschacky@med.uni-muenchen.de
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