Document Detail

Use of recombinant human interferon gamma to enhance neutrophil chemotactic responses in Job syndrome of hyperimmunoglobulinemia E and recurrent infections.
MedLine Citation:
PMID:  1900333     Owner:  NLM     Status:  MEDLINE    
Recombinant human interferon gamma enhances neutrophil respiratory burst and bactericidal activity in patients with chronic granulomatous disease. Mononuclear leukocytes of patients with the hyperimmunoglobulinemia E syndrome (Job syndrome) produce low or undetectable levels of this lymphokine. For these reasons we have restudied neutrophil chemotaxis in a group of our patients with the syndrome and determined the effect of recombinant human interferon gamma on the responses. Each of the patients had neutrophil chemotactic responses ranging from 22% to 55% of simultaneous control values (p less than 0.001). After incubation with interferon gamma, a significant improvement in chemotactic responsiveness was observed in the neutrophils of each of the patients (mean 301% of baseline chemotaxis; p less than 0.008). These data suggest the need for a double-blind, placebo-controlled trial of interferon gamma in a larger group of patients with the syndrome of hyperimmunoglobulinemia E and recurrent infections.
J D Jeppson; H S Jaffe; H R Hill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  118     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-05     Completed Date:  1991-04-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
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MeSH Terms
Bacterial Infections / blood*,  physiopathology
Chemotaxis, Leukocyte / physiology*
Child, Preschool
Hypergammaglobulinemia / blood*,  physiopathology
Immunoglobulin A / analysis
Immunoglobulin E* / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Interferon-gamma, Recombinant / pharmacology*
Job's Syndrome / blood*,  physiopathology
Neutrophils / physiology*
Grant Support
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Interferon-gamma, Recombinant; 37341-29-0/Immunoglobulin E

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