Document Detail


Use of quinolones in chlamydial infection.
MedLine Citation:
PMID:  2672254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of fluoroquinolones against Chlamydia trachomatis has been studied in vitro. Those agents with an MIC of less than 2.0 mg/L may be of clinical value, and clinical trials have been conducted with ciprofloxacin, ofloxacin, and fleroxacin. Ciprofloxacin has given variable results in the treatment of Chlamydia-positive urethritis in men; some studies have shown an unacceptably high reisolation of the organisms with prolonged posttreatment surveillance. Ofloxacin may be an effective drug for the treatment of lower genital tract infections with C. trachomatis in men and women, and there are indications that ofloxacin may also be of value in the treatment of chlamydial epididymitis and salpingitis. Early studies of fleroxacin suggest that this drug may also be an effective antichlamydial agent.
Authors:
J D Oriel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  11 Suppl 5     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-10-06     Completed Date:  1989-10-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S1273-6     Citation Subset:  IM    
Affiliation:
Department of Genito-urinary Medicine, University College Hospital, London, England, U.K.
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MeSH Terms
Descriptor/Qualifier:
4-Quinolones
Anti-Infective Agents / pharmacology,  therapeutic use*
Chlamydia Infections / drug therapy*
Chlamydia trachomatis / drug effects
Humans
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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