| Use of pulse wave and color flow Doppler echocardiography in mouse models of human disease. | |
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MedLine Citation:
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PMID: 12094169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The noninvasive assessment of cardiovascular physiology in mice is challenging because of their small size and extremely rapid heart rates. In this study, we sought to determine the feasibility and utility of pulse wave (PW) and color flow Doppler imaging techniques when applied to mouse models of cardiac remodeling. We performed transverse aortic banding, induced aortic insufficiency (AI), or sham procedures in wild-type mice. Animals were anesthetized and transthoracic echocardiography was performed, including PW and color flow Doppler imaging. In aortic banded mice, color flow Doppler imaging was used to identify flow around the aortic arch, and PW measurements were performed distal to the constriction. A high-velocity jet across the aortic constriction was detected in all 4 banded animals. Both modalities were applied to AI mice in which AI was detected in all 5 mice but in none of the 5 shams. Pulse wave and color flow Doppler imaging were also used to screen senescent mice for valve abnormalities; AI was detected in 3 of 20 and mitral regurgitation in 2 of 20. We demonstrate here that PW and color flow Doppler imaging techniques are useful in the evaluation of mouse models of cardiac remodeling. In addition, this study indicates that these modalities may be potentially useful to screen transgenic mice for valve abnormalities. |
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Authors:
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Richard D Patten; Mark J Aronovitz; Paul Bridgman; Natesa G Pandian |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 15 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-02 Completed Date: 2002-09-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 708-14 Citation Subset: IM |
Affiliation:
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Division of Cardiology and the Molecular Cardiology Research Institute, Department of Medicine, New England Medical Center, Boston, 02111, USA. RPatten@lifespan.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Valve Insufficiency / ultrasonography* Disease Models, Animal* Echocardiography, Doppler, Color* Echocardiography, Doppler, Pulsed* Feasibility Studies Hypertrophy, Left Ventricular / ultrasonography* Mice Mice, Inbred C57BL Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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HL03598/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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