Document Detail

Use of prostaglandin E2 for cervical ripening in pregnancies with oligohydramnios.
MedLine Citation:
PMID:  11014946     Owner:  NLM     Status:  MEDLINE    
The effectiveness of intracervical prostaglandin E2 (PGE2) was studied in 96 primigravidas with unfavorable cervix and need for induction of labor. Group A consisted of 49 oligohydramnios and group B of 47 cases with normal amniotic fluid volume (controls). A single dose of 0.5 mg PGE2 gel was applied intracervically and several parameters were recorded during the next hours. The mean number of uterine contractions increased during the first 2 h in both groups, decreased during the next one and did not change significantly afterwards. The mean fetal heart rate (FHR) in group A decreased during the first 2 h and then increased, staying always within normal limits. The mean FHR in group B increased for 2 h, decreased during the next hour and did not change significantly afterwards. No significant differences were found between the two groups regarding mode of delivery, Apgar score and neonatal acidosis. Intracervical PGE2 appeared to effectively stimulate cervical ripening and labor induction in oligohydramnios, without causing side effects to the uterus and fetus.
T Stefos; E Mouzakioti; A Sotiriadis; S Andronikou; K Adamidis; D Lolis
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  50     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  158-61     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Obstetrics and Gynecology, University of Ioannina, Greece.
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MeSH Terms
Cervical Ripening* / drug effects
Dinoprostone / administration & dosage,  therapeutic use*
Oxytocics / administration & dosage,  therapeutic use*
Pregnancy Outcome
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone

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