Document Detail

Use of propofol for induction of anesthesia in dogs undergoing definitive radiation therapy: 31 cases (2006-2009).
MedLine Citation:
PMID:  23013502     Owner:  NLM     Status:  In-Data-Review    
Objective-To evaluate changes in serial hemograms and serum biochemical profiles in tumor-bearing dogs undergoing daily anesthesia with propofol as an induction agent for radiation therapy. Design-Retrospective case series. Animals-31 dogs with cutaneous or subcutaneous malignancies over the trunk or limbs. Procedures-Radiation therapy consisted of 18 daily treatments administered Monday through Friday over a period of 24 days. Propofol was administered IV to effect for induction of anesthesia. Complete blood count and serum biochemical data were generated at the beginning, middle, and end of radiation therapy and compared to identify changes over time via either a repeated-measures ANOVA or Friedman test. Results-Leukocyte and platelet parameters did not differ significantly over time. Calculated Hct, erythrocyte count, hemoglobin concentration, and mean corpuscular hemoglobin concentration decreased overtime, whereas mean corpuscular volume increased overtime. Conclusions and Clinical Relevance-Dogs receiving propofol for induction of anesthesia and radiation therapy had a decrease in RBC count, although these changes were not determined to be of clinical importance in this patient population. The cause of these alterations was not immediately apparent. Propofol appeared to be a safe choice for induction of anesthesia in dogs during daily radiation therapy.
Todd M Erfourth; Elizabeth A McNiel; Michael A Scott; Deborah V Wilson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  241     ISSN:  1943-569X     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  898-903     Citation Subset:  IM    
Departments of Small Animal Clinical Sciences and Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824.
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