Document Detail

Use of prognostic factors in analysis of historical control studies.
MedLine Citation:
PMID:  7407774     Owner:  NLM     Status:  MEDLINE    
This paper considers the use of regression methods for the interpretation of comparative results between treatments in historical control studies. A logistic regression model is used for response rate studies and Cox's regression model for studies of disease-free or overall survival. For both models, stepwise regression procedures may be utilized to test for treatment differences adjusting for differences in patient characteristics between the treatment groups. Examples are given from two clinical studies: the first example concerned a study which compared disease-free and overall survival experience between patients receiving surgery plus radiation therapy plus FAC-BCG (5-fluorouracil, Adriamycin, and cyclophosphamide-bacillus Calmette-Guérin) as adjuvant treatment compared with surgery plus radiation therapy alone for patients with stage II or III breast cancer; the second example concerned a study of acute leukemia in which differences among complete remission rats by institution were interpreted using a logistic regression equation to adjust for prognostic factors.
E A Gehan; T L Smith; A U Buzdar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer treatment reports     Volume:  64     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:    1980 Feb-Mar
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / therapeutic use
Breast Neoplasms / therapy
Clinical Trials as Topic / methods*
Leukemia / therapy
Middle Aged
Models, Biological
Neoplasms / therapy*
Regression Analysis*
Retrospective Studies
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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