| Use of a progestogen only preparation containing desogestrel in the treatment of recurrent pelvic pain after conservative surgery for endometriosis. | |
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MedLine Citation:
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PMID: 16963174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effect of a new progestin progestogen only pill (desogestrel) versus an oral contraceptive in the treatment of recurrent endometriosis. STUDY DESIGN: A randomized prospective clinical study. A group of women with endometriosis (n=40) who showed recurrent dysmenorrhea and/or pelvic pain after conservative surgery, and did not desire a pregnancy. Continuous treatment for 6 months with desogestrel (75 microg/d) (n=20) versus a combined oral contraceptive (ethinyl estradiol 20 microg plus desogestrel 150 microg) (n=20) was performed. RESULTS: A significant improvement of both pelvic pain and dysmenorrhea was observed following each type of treatment (P<0.001). The use of desogestrel progestogen only pill was associated with a breakthrough bleeding in 20% patients, while a significant body weight increase was observed in 15% after oral contraceptive. CONCLUSIONS: Both desogestrel and an oral estro-progestinic were effective, safe and low cost therapy of pain symptoms after endoscopic surgery for endometriosis, the former showing an impact on breakthrough bleeding, the later an incidence on body weight increase. |
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Authors:
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Sandro Razzi; Stefano Luisi; Caterina Ferretti; Francesco Calonaci; Massimo Gabbanini; Massimo Mazzini; Felice Petraglia |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2006-09-11 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 135 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 188-90 Citation Subset: IM |
Affiliation:
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Chair of Obstetrics and Gynecology, Department of Pediatric, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Desogestrel / therapeutic use* Endometriosis / blood, drug therapy*, surgery Ethinyl Estradiol / therapeutic use* Female Humans Metrorrhagia / drug therapy, etiology Pelvic Pain / drug therapy* Progestins / therapeutic use* Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Progestins; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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