Document Detail


Use of pressure drop profiles to assess the accuracy of Total Pore Blocking measurements of the external porosity of chromatographic columns.
MedLine Citation:
PMID:  21600578     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
By comparing the pressure drop in a column where the meso-pores of the particles have been blocked using the Total Pore Blocking (TPB) method to measure the interstitial volume of the column with that in the same column when the particle meso-pores are fully open, it could be demonstrated in a very sensitive way that the interstitial volume is completely devoid of any significant amount of remaining pore blocking agent in the final phase of a TPB experiment. Monitoring the pressure signal until it returns to its original value can hence be used as a reliable indicator that all blocking agent has been removed from the interstitial void at the end of the flushing period. As a consequence, any small molecular weight dead volume marker that is employed in this phase can explore the full interstitial volume, so that the value of the latter can be measured without being underestimated by the fact that some fractions of the interstitial void would still be occupied by the blocking agent.
Authors:
Anuschka Liekens; Joeri Denayer; Gert Desmet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-6
Journal Detail:
Title:  Journal of chromatography. A     Volume:  -     ISSN:  1873-3778     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium.
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