Document Detail

Use of pressor therapy in 34 hypotensive critically ill neonatal foals.
MedLine Citation:
PMID:  21091458     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Arginine vasopressin (AVP) is used in human medicine in the management of vasodilatory shock and cardiac arrest, but it is not widely used in equine neonatal intensive care because of concerns about potential side effects and suboptimal efficacy. This retrospective study reports the clinical use of AVP and norepinephrine (NE) in foals with refractory hypotension.
OBJECTIVES: To report the cardiovascular responses and fluid balance in critically ill, hypotensive foals receiving either NE or AVP.
DESIGN: The medical records of neonatal foals (<7 days of age) from 2000 to 2007 admitted to the Marion duPont Scott Equine Medical Center were reviewed.
RESULTS: The use of exogenous AVP infusion was associated with a significant increase in mean arterial pressure (MAP) and urinary output, and a significant decrease in heart rate. NE administration was also associated with a significant increase in MAP.
CONCLUSIONS: The findings of this first report of the clinical treatment of foals with refractory hypotension support the use of AVP and NE.
E J Dickey; H C McKenzie; A Johnson; M O Furr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  88     ISSN:  1751-0813     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  472-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Australian Veterinary Journal © 2010 Australian Veterinary Association.
Department of Neonatal Research, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia.
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MeSH Terms
Animals, Newborn
Arginine Vasopressin / therapeutic use*
Blood Pressure / drug effects
Heart Rate / drug effects
Horse Diseases / drug therapy*
Hypotension / drug therapy,  veterinary*
Norepinephrine / therapeutic use*
Retrospective Studies
Treatment Outcome
Urination / drug effects
Vasoconstrictor Agents / therapeutic use*
Water-Electrolyte Balance / physiology
Reg. No./Substance:
0/Vasoconstrictor Agents; 113-79-1/Arginine Vasopressin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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