Document Detail


Use of prenatal phenobarbital in the prevention of subependymal/intraventricular hemorrhage in premature infants.
MedLine Citation:
PMID:  9775459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Subependymal/intraventricular hemorrhage (SE/IVH) is a frequent cause of disability and mortality. METHODS: This is a prospective, randomized, double-blind study which included 100 pregnant Mexican women who need to interrupt their pregnancy within 28-32 weeks of gestation. One group was given a single dose of intravenous (IV) phenobarbital 10 micrograms/kg (phenobarbital group, n = 50), and the other was provided with diluted distilled water (control group). Measurements of phenobarbital serum concentrations were taken by both mother and newborn, and head sonograms were applied during the first 24 hours, at the 3rd and 7th days of life. RESULTS: The sample was made up of 42 newborns in the phenobarbital group, and 46 in the control group; the newborns had phenobarbital levels of 11.5 5.7 g/microliter at birth, and of 9.5 +/- 5.9 g/microliter 24 hours later. SE/IVH was found in 12 patients from the phenobarbital group and in 29 from the control group (p < 0.005), the first group were 11 mild SE/IVH (2 grade I, and 9 grade II), and 26 in the control group (4 grade I, and 22 grade II), p < 0.005. Severe hemorrhages were similar between groups. A larger frequency of SE/IVH was found in the newborn group which received mechanical ventilation (p = 0.0008). CONCLUSIONS: Prenatal phenobarbital can reduce the SE/IVH frequency in premature infants younger than 32 weeks at birth. Its main effect could be shown in patients with mechanical ventilation.
Authors:
L M Arroyo-Cabrales; S Garza-Morales; G Hernández-Peláez
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of medical research     Volume:  29     ISSN:  0188-4409     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  1998  
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  MEXICO    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Affiliation:
Unidad de Neonatología de Cuidado Intermedio, Instituto Nacional de Perinatología, México, D.F. sgm@starnet.net.mx
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Hemorrhage / prevention & control*
Cerebral Ventricles
Double-Blind Method
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Mexico
Phenobarbital / administration & dosage,  therapeutic use*
Pregnancy
Prenatal Care*
Prospective Studies
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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