Document Detail

Use of povidone-iodine during the first trimester of pregnancy: a correct practice?
MedLine Citation:
PMID:  19187379     Owner:  NLM     Status:  MEDLINE    
Povidone-iodine (PVP-I) has been widely used as an antiseptic agent during invasive procedures for prenatal diagnosis. Women have been reported of thyroid dysfunction after simple exposure to PVP-I. We studied the effect on thyroid function and urinary iodine excretion after a single topical application of PVP-I in 31 women who had a miscarriage during the first trimester of pregnancy. PVP-I is absorbed through the skin and the vaginal mucosa, resulting in a sudden increase in the urinary excretion of iodine and a short-term variation in concentrations of thyroid hormones in maternal serum. This metabolic effect could have consequences for the embryo and the fetus during crucial stages of development.
I Velasco; S Naranjo; C López-Pedrera; M J Garriga; E García-Fuentes; F Soriguer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-5     Citation Subset:  AIM; IM    
Servicio de Obstetricia y Ginecología, Hospital de Osuna, Sevilla, Spain.
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MeSH Terms
Abortion, Spontaneous / surgery*
Anti-Infective Agents, Local / adverse effects*,  pharmacokinetics,  urine
Dilatation and Curettage*
Povidone-Iodine / adverse effects*,  pharmacokinetics
Pregnancy Complications / chemically induced*
Pregnancy Trimester, First
Prospective Studies
Thyroid Diseases / chemically induced*
Thyrotropin / metabolism
Thyroxine / metabolism
Reg. No./Substance:
0/Anti-Infective Agents, Local; 25655-41-8/Povidone-Iodine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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