Document Detail

Use of plasma Epstein-Barr virus DNA monitoring as a tumor marker in follow-up of patients with nasopharyngeal carcinoma: preliminary results and report of two cases.
MedLine Citation:
PMID:  17922462     Owner:  NLM     Status:  MEDLINE    
Recent studies suggest that plasma Epstein-Barr virus (EBV) DNA may reflect tumor burden in patients with nasopharyngeal cancer. A prospective study was initiated to investigate this correlation in 125 patients (34 pretreatment [Group A], 78 in remission [Group B] and 13 relapsed [Group C]) and 19 healthy controls. In group A, EBV DNA was detected in plasma samples of 24 (70%) patients. In Group B, EBV DNA was detected in 7 patients (range 77-13,731 copies/mL) and further imaging in all but one of these patients revealed active disease confirmed by ultrasound-guided fine-needle biopsy. There was only one false-positive case; this patient is currently under follow-up. Here we describe 2 of the 7 patients with detectable plasma EBV DNA in whom recurrence was documented by PET scan during follow-up. Our results showed that in group B the positive predictive value of quantitative analysis of plasma EBV DNA was 85%. Quantitative analysis of EBV DNA in plasma seems to become an integral part of screening, staging, monitoring, and prediction of relapse in patients with nasopharyngeal carcinoma. However, previous studies cannot be considered definitive and more reports on the use of this technique are urgently needed from both endemic and non-endemic regions.
E Ozyar; M Gültekin; A Alp; G Hasçelik; O Ugur; I L Atahan
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of biological markers     Volume:  22     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-10-08     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  194-9     Citation Subset:  IM    
Department of Radiation Oncology, Oncology Institute, Hacettepe University, 06532 Ankara, Turkey.
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MeSH Terms
DNA, Viral / blood*,  genetics
Epstein-Barr Virus Infections / blood,  complications,  virology*
Fluorodeoxyglucose F18 / diagnostic use
Herpesvirus 4, Human / genetics*
Middle Aged
Nasopharyngeal Neoplasms / blood,  pathology,  radionuclide imaging,  virology*
Neoplasm Recurrence, Local / blood,  genetics,  radionuclide imaging,  virology
Neoplasm Staging
Polymerase Chain Reaction / methods
Positron-Emission Tomography
Prospective Studies
Radiopharmaceuticals / diagnostic use
Tumor Markers, Biological / blood*,  genetics
Reg. No./Substance:
0/DNA, Viral; 0/Radiopharmaceuticals; 0/Tumor Markers, Biological; 63503-12-8/Fluorodeoxyglucose F18

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