Document Detail


Use of the placenta as an artificial lung.
MedLine Citation:
PMID:  10826732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxygen transfer across a single cotyledon of the human placenta was assessed by using three different perfusates in the maternal circuit: 1) M-199 culture medium, 2) human adult red blood cells (RBCs), and 3) perflubron. These maternal circuit perfusates were oxygenated with a membrane oxygenator. RBCs were perfused on the fetal side of the circuit and samples were taken preplacenta and postplacenta for each maternal perfusate. PO2 and PCO2 were measured and O2 transfer was calculated for each maternal perfusate. O2 transfer per single cotyledon (mean +/- SE) was 0.18 +/- 0.04, 0.20 +/- 0.03, and 0.15 +/- 0.05 ccO2/min when using: 1) M-199, 2) RBCs, and 3) perflubron, respectively. O2 transfer per kilogram of placental tissue was 13.08 +/- 2.78, 14.57 +/- 2.05, and 10.43 +/- 3.79 ccO2/kg per minute when using: 1) M-199, 2) RBCs, and 3) perflubron, respectively. When extrapolated to the individual weights of the entire placenta, the O2 transfer was 9.15 +/- 1.95, 10.20 +/- 1.43, and 7.30 +/- 2.65 when using: 1) M-199, 2) RBCs, and 3) perflubron, respectively. We conclude from these data that O2 transfer can be accomplished during placental perfusion. Larger studies are required to differentiate efficacy among the three maternal circuit perfusates.
Authors:
S Sawada; C A Reickert; R H Bartlett; R B Hirschl
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  46     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-08-04     Completed Date:  2000-08-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0245, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Artificial Organs*
Biological Transport / drug effects,  physiology
Blood Substitutes / pharmacology
Carbon Dioxide / metabolism
Culture Media / pharmacology
Erythrocytes / metabolism
Extracorporeal Membrane Oxygenation / methods
Female
Fluorocarbons / pharmacology
Humans
Lung*
Lung Diseases / therapy*
Oxygen / pharmacokinetics*
Perfusion
Placenta / blood supply,  metabolism*
Grant Support
ID/Acronym/Agency:
R29 HL54224/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Culture Media; 0/Fluorocarbons; 124-38-9/Carbon Dioxide; 423-55-2/perflubron; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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