Document Detail


Use of peptide nucleic acid-fluorescence in situ hybridization for definitive, rapid identification of five common Candida species.
MedLine Citation:
PMID:  17804657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated a 2.5-h peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) assay with five Candida species-specific probes to identify Candida colonies and compared it to standard 2-h to 5-day phenotypic identification methods. Suspensions were made and slides were prepared and read for fluorescence per the manufacturer's instructions. Sensitivity was 99% (109/110), and specificity was 99% (129/130). PNA-FISH can rapidly identify those Candida species isolated most frequently.
Authors:
Megan E Reller; Amanda B Mallonee; Nicole P Kwiatkowski; William G Merz
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Publication Detail:
Type:  Journal Article     Date:  2007-09-05
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  45     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-12-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3802-3     Citation Subset:  IM    
Affiliation:
Medical Microbiology Division, Department Pathology, Meyer B1-193, The Johns Hopkins Hospital, Baltimore, MD 21287-7093, USA.
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MeSH Terms
Descriptor/Qualifier:
Candida / isolation & purification*
Humans
In Situ Hybridization, Fluorescence / methods*
Nucleic Acid Probes / genetics*
Peptide Nucleic Acids / genetics*
Chemical
Reg. No./Substance:
0/Nucleic Acid Probes; 0/Peptide Nucleic Acids
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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