Document Detail


Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
MedLine Citation:
PMID:  23410198     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Paracetamol is frequently prescribed for pain and fever control in acute stroke patients, but its effect on stroke outcome is unclear. The aim was to investigate the safety and benefit of paracetamol administration in the acute phase of ischaemic stroke. METHODS: We analysed the impact of paracetamol exposure on functional outcome at 90 days among ischaemic stroke patients registered in a clinical trials archive. We used an adjusted Cochran-Mantel-Haenszel test to test for significance (P) followed by proportional odds logistic regression analysis to estimate the odds ratios (OR) for more favourable modified Rankin Scale score. RESULTS: Data were available for 6015 patients, of whom 2435 had received paracetamol. No association of paracetamol-use with overall stroke outcome could be detected among those patients who experienced pain and/or fever (OR 1.03, 95% CI 0.86-1.20, P = 0.931). In patients without recorded pain and/or fever events and a baseline temperature below 37°C, in whom paracetamol was started within 3 days of stroke, paracetamol was associated with worse outcome (OR 0.58, 95% CI 0.47-0.72, P = <0.001). CONCLUSION: This retrospective analysis is discouraging for prophylactic use of paracetamol in acute stroke patients, but underlines the need for a sufficiently powered randomized controlled trial.
Authors:
B Frank; R L Fulton; C Weimar; K R Lees; R D Sanders;
Related Documents :
24373638 - Neurological outcome after emergency radiotherapy in mscc of patients with non-small ce...
22815118 - Patient classification and hospital costs of care for stroke in 10 european countries.
16476948 - Silent microbleeds are associated with volume of primary intracerebral hemorrhage.
15357778 - Hla class ii genotype and factor viii inhibitors in mild haemophilia a patients with an...
22048928 - Neuroleptic-induced catatonia in two hospitalized patients.
24150958 - Simiff study: italian fungal registry of mold infections in hematological and non-hemat...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  -     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Department of Medicine and Therapeutics, Faculty of Medicine, University of Glasgow, Western Infirmary, Glasgow, UK; Department of Neurology, University of Duisburg-Essen, Essen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The mediating effects of structural empowerment on job satisfaction for nurses in long-term care fac...
Next Document:  Geminal Bis(silyl) Enal: A Versatile Scaffold for Stereoselective Synthesizing C(3),O(1)-Disilylated...