Document Detail


Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction.
MedLine Citation:
PMID:  21330007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory syncytial virus (RSV) is a potentially life-threatening infection in premature infants. We report an outbreak involving four infants in the neonatal intensive care unit (NICU) of our hospital that occurred in February 2010. RSV A infection was confirmed by real-time polymerase chain reaction. Palivizumab was administered to all infants in the NICU. There were no additional symptomatic cases and repeat RSV surveillance confirmed that there was no further cross-transmission within the unit. The outbreak highlighted the infection control challenge of very high bed occupancy in the unit and the usefulness of molecular methods in facilitating detection and management.
Authors:
K O'Connell; T W Boo; D Keady; U Niriain; D O'Donovan; M Commane; C Faherty; M Cormican
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-16
Journal Detail:
Title:  The Journal of hospital infection     Volume:  77     ISSN:  1532-2939     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-18     Revised Date:  2012-09-13    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 the Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Clinical Microbiology, University College Hospital, Galway, Ireland. karinaoconnell@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized
Antiviral Agents / administration & dosage*
Cross Infection / drug therapy,  epidemiology*,  prevention & control
DNA, Viral / genetics,  isolation & purification
Disease Outbreaks*
Female
Genotype
Humans
Infant
Infant, Newborn
Infection Control / methods
Intensive Care, Neonatal
Polymerase Chain Reaction
Respiratory Syncytial Virus Infections / drug therapy,  epidemiology*,  prevention & control
Respiratory Syncytial Virus, Human / classification,  drug effects,  genetics,  isolation & purification*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antiviral Agents; 0/DNA, Viral; 0/palivizumab
Comments/Corrections
Comment In:
J Hosp Infect. 2012 Aug;81(4):292-3   [PMID:  22727129 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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