Document Detail

Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction.
MedLine Citation:
PMID:  21330007     Owner:  NLM     Status:  MEDLINE    
Respiratory syncytial virus (RSV) is a potentially life-threatening infection in premature infants. We report an outbreak involving four infants in the neonatal intensive care unit (NICU) of our hospital that occurred in February 2010. RSV A infection was confirmed by real-time polymerase chain reaction. Palivizumab was administered to all infants in the NICU. There were no additional symptomatic cases and repeat RSV surveillance confirmed that there was no further cross-transmission within the unit. The outbreak highlighted the infection control challenge of very high bed occupancy in the unit and the usefulness of molecular methods in facilitating detection and management.
K O'Connell; T W Boo; D Keady; U Niriain; D O'Donovan; M Commane; C Faherty; M Cormican
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-16
Journal Detail:
Title:  The Journal of hospital infection     Volume:  77     ISSN:  1532-2939     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-18     Revised Date:  2012-09-13    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 the Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Department of Clinical Microbiology, University College Hospital, Galway, Ireland.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal, Humanized
Antiviral Agents / administration & dosage*
Cross Infection / drug therapy,  epidemiology*,  prevention & control
DNA, Viral / genetics,  isolation & purification
Disease Outbreaks*
Infant, Newborn
Infection Control / methods
Intensive Care, Neonatal
Polymerase Chain Reaction
Respiratory Syncytial Virus Infections / drug therapy,  epidemiology*,  prevention & control
Respiratory Syncytial Virus, Human / classification,  drug effects,  genetics,  isolation & purification*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antiviral Agents; 0/DNA, Viral; 0/palivizumab
Comment In:
J Hosp Infect. 2012 Aug;81(4):292-3   [PMID:  22727129 ]

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