| Use of oxytocin during early stages of labor and its effect on active management of third stage of labor. | |
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MedLine Citation:
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PMID: 21145034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate whether the use of oxytocin during the first and second stages of labor is associated with a higher incidence of postpartum hemorrhage (PPH) in pregnant women who received active management of third stage of labor (AMTSL). STUDY DESIGN: A secondary data analysis from vaginal deliveries in a hospital-based cohort study from 24 maternity hospitals in South America. The primary outcomes that were analyzed were moderate PPH (≥500 mL of blood loss), severe PPH (≥1000 mL of blood loss), and need of blood transfusion. RESULTS: A total of 11,323 vaginal deliveries were included. The incidence of moderate and severe PPH was 10.8% and 1.86%, respectively. Overall, 36% of deliveries received AMTSL. There was no association between induced/augmented labor and moderate PPH (P = .753), severe PPH (P = .273), and blood transfusion (P = .603) in the population that received AMTSL. CONCLUSION: AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor. |
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Authors:
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Claudio G Sosa; Fernando Althabe; José M Belizan; Pierre Buekens |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-12-08 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 204 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-06-29 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 238.e1-5 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine, University of Uruguay, Montevideo, Uruguay. csosa@tulane.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Delivery, Obstetric / methods Female Humans Incidence Labor Stage, First Labor Stage, Second Labor Stage, Third / drug effects* Oxytocics / administration & dosage*, adverse effects Oxytocin / administration & dosage*, adverse effects Postpartum Hemorrhage / chemically induced, etiology* Pregnancy Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW005492-06/TW/FIC NIH HHS; R01 TW007600-04/TW/FIC NIH HHS; TW05492/TW/FIC NIH HHS; U01 HD040477-05/HD/NICHD NIH HHS; U01HD040477/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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