Document Detail

Use of ovarian reserve tests for the prediction of ongoing pregnancy in couples with unexplained or mild male infertility.
MedLine Citation:
PMID:  16478583     Owner:  NLM     Status:  MEDLINE    
The chance of infertile patients conceiving is related to factors like female age and duration of infertility. This prospective observational study evaluated whether the results of ovarian reserve tests, including the novel marker serum anti-Mullerian hormone (AMH), were of additional value in predicting ongoing pregnancy. Two hundred and twenty-two patients diagnosed with unexplained infertility or mild male factor (total motile count>10x10(6)) on the basis of the infertility work-up were prospectively included. Antral follicle count, AMH, inhibin B, FSH and oestradiol concentrations were determined during the early follicular phase. Outcome measures were treatment-dependent and treatment-independent ongoing pregnancy and time to ongoing pregnancy. There were 159 ongoing pregnancies, 52 of which occurred spontaneously. Pregnant patients were significantly younger than those who did not become pregnant (median age 32.4 versus 34.9 years, P<0.001) and FSH concentrations were higher in non-pregnant patients (median 6.8 versus 7.6 IU/l, P=0.04). Only age (hazard ratio 0.93, 95% CI 0.90-0.97) and whether or not the patient was undergoing treatment (hazard ratio 8.10, 95% CI 5.66-11.61) were significantly associated with time to ongoing pregnancy. Ovarian reserve tests, other than chronological age, seem of limited value in predicting (time to) ongoing pregnancy in patients with unexplained and mild male infertility.
Ilse A J van Rooij; Frank J M Broekmans; Claudine C Hunault; Gabriëlle J Scheffer; Marinus J C Eijkemans; Frank H de Jong; Axel P N Themmen; Egbert R te Velde
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  12     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-15     Completed Date:  2006-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-90     Citation Subset:  IM    
Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
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MeSH Terms
Estradiol / blood
Follicle Stimulating Hormone / blood
Infertility, Male / physiopathology*
Inhibins / blood
Ovarian Follicle
Ovary / physiology*
Pregnancy / physiology*
Pregnancy Outcome
Prospective Studies
Reg. No./Substance:
0/inhibin B; 50-28-2/Estradiol; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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