Document Detail


Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: the ENIGMA study.
MedLine Citation:
PMID:  21505350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The oral contraceptive pill (OCP) is widely prescribed throughout the world. Although it is associated with a small but significant increase in blood pressure, the influence of the OCP on large artery stiffness and wave reflection is unclear. The aim of this study was to determine the relationship between use of the OCP and aortic stiffness and wave reflections in a young, healthy cohort of women.
METHODS: Participants were drawn from the ENIGMA study, which examines the natural history of blood pressure in young adults. A detailed medical history and lifestyle questionnaire, including OCP details were taken. Blood pressure was measured according to the British Hypertension Society guidelines. Aortic pulse wave velocity (aPWV) was measured together with augmentation index (AIx). Stroke volume (SV) and cardiac output (CO) were also assessed.
RESULTS: Women taking the OCP (n = 225) had a higher SBP and pulse pressure compared with nonusers (n = 660; 112 ± 12 vs. 110 ± 11 and 43 ± 8 vs. 42 ± 8 mmHg, respectively, P < 0.05 for both). CO and SV were also higher (6.6 ± 1.5 vs. 6.3 ± 1.5 l/min, P < 0.01 and 81 ± 16 vs. 78 ± 19 ml, P < 0.05) as was aPWV (5.5 ± 0.7 vs. 5.4 ± 0.7 m/s, P < 0.05). However, there was no difference in DBP (68 ± 9 vs. 69 ± 9 mmHg), mean arterial pressure (81 ± 10 vs. 81 ± 10 mmHg) or AIx (2 ± 12 vs. 3 ± 13%) between the groups.
CONCLUSION: Use of the OCP is associated with elevated pulse pressure and SV and a small increase in aPWV in young women. The longer term implications of these effects require further investigation.
Authors:
Stacey S Hickson; Karen L Miles; Barry J McDonnell; Yasmin; John R Cockcroft; Ian B Wilkinson; Carmel M McEniery;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  29     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-05     Completed Date:  2011-09-15     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1155-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arteries / drug effects*,  physiology
Cohort Studies
Compliance / drug effects*
Contraceptives, Oral / adverse effects*
Female
Hemodynamics
Humans
Grant Support
ID/Acronym/Agency:
FS/07/001/21990//British Heart Foundation; //British Heart Foundation
Chemical
Reg. No./Substance:
0/Contraceptives, Oral
Investigator
Investigator/Affiliation:
Samantha Benedict / ; John Cockcroft / ; Lisa Day / ; Zahid Dhakam / ; Stacey Hickson / ; Julia Howard / ; Kaisa Maki-Petaja / ; Barry McDonnell / ; Carmel McEniery / ; Karen Miles / ; Maggie Munnery / ; Pawan Pusalkar / ; Christopher Retallick / ; Ramsey Sabit / ; James Sharman / ; Jane Smith / ; Rachel Stainsby / ; Edna Thomas / ; Sharon Wallace / ; Ian Wilkinson / ; Jean Woodcock-Smith /
Comments/Corrections
Comment In:
J Hypertens. 2011 Oct;29(10):2042-4; author reply 2044-5   [PMID:  21904160 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Combining blockers of the renin-angiotensin system or increasing the dose of an angiotensin II recep...
Next Document:  Comparison of central pressure estimates obtained from SphygmoCor, Omron HEM-9000AI and carotid appl...