Document Detail

Use of opioids in a Danish population-based cohort of cancer patients.
MedLine Citation:
PMID:  15857736     Owner:  NLM     Status:  MEDLINE    
Until recently, Denmark has had the highest use of strong opioids per capita in the world. Our aim was to analyze cancer patients' use of opioids in this population by linkage between the Danish Cancer Register and a prescription database. The changes in opioid use from 1994 to 1998 in the entire cohort of cancer patients (n=24,190) in a Danish county (n approximately 470,000) were analyzed. The overall consumption of opioids increased from 20 kg to 37 kg oral morphine equivalents (omeq) per year. The average consumption increased from 7.6 to 10.7 g omeq/opioid user/year. The annual proportion of users increased from 17% to 20%. The proportion of patients who were alive 2 years after their first opioid prescription increased from 38% to 55%. Increased awareness towards pain treatment, with earlier initiation of opioid treatment and higher doses to the cancer patients, could be major explanations for the increase in the cancer patients' use of opioids.
Lene Jarlbaek; Morten Andersen; Jesper Hallas; Gerda Engholm; Jakob Kragstrup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  29     ISSN:  0885-3924     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-28     Completed Date:  2005-06-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-43     Citation Subset:  IM    
Research Unit of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
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MeSH Terms
Cohort Studies
Denmark / epidemiology
Drug Prescriptions / statistics & numerical data*
Drug Utilization
Narcotics / therapeutic use*
Neoplasms / drug therapy,  mortality*
Pain / drug therapy*,  mortality*
Palliative Care / statistics & numerical data*,  trends
Retrospective Studies
Survival Analysis
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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