Document Detail

Use of octreotide to treat prolonged sulfonylurea-induced hypoglycemia in a patient with chronic renal failure.
MedLine Citation:
PMID:  12602474     Owner:  NLM     Status:  MEDLINE    
A diabetic patient with chronic renal failure who developed recurrent and prolonged episodes of hypoglycemia associated with use of sulfonylurea agent is presented here. This patient was hospitalized with neuroglycopenic symptoms of hypoglycemia that persisted in spite of large doses of parenteral glucose replacement. On administration of somatostatin analogue octreotide, hypoglycemia resolved and, blood glucose levels were maintained even after cessation of parenteral glucose. The patient received 2 subcutaneous doses of octreotide 12 hours apart, and made a complete recovery. Our experience suggests that use of octerotide to treat refractory or prolonged sulfonylurea-included hypoglycemia in renal failure patients is safe and effective; large prospective studies would be needed to validate these findings.
C M Nzerue; J Thomas; J Volcy; T Edeki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  26     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
Department of Medicine, Renal Section, University of Rochester School of Medicine, Rochester, NY 14642, USA.
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MeSH Terms
C-Peptide / blood
Diabetes Mellitus, Type 2 / complications,  drug therapy*
Gastrointestinal Agents / therapeutic use*
Glipizide / adverse effects*,  therapeutic use
Hypoglycemia / chemically induced,  drug therapy*
Hypoglycemic Agents / adverse effects*,  therapeutic use
Kidney Failure, Chronic / complications*
Octreotide / therapeutic use*
Seizures / etiology
Reg. No./Substance:
0/C-Peptide; 0/Gastrointestinal Agents; 0/Hypoglycemic Agents; 29094-61-9/Glipizide; 83150-76-9/Octreotide

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