Document Detail


Use of non-invasive-stimulated muscle force assessment in long-term critically ill patients: a future standard in the intensive care unit?
MedLine Citation:
PMID:  17714574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study's main purpose was to test the feasibility of employing a non-invasive-stimulated muscle force assessment approach in long-term critically ill patients. METHODS: A case series was performed over a 4-year period in the intensive care unit (ICU). Of the 25 patients initially recruited, eight patients required long-time mechanical ventilation for a median of 3.8 weeks (range 2-10 weeks) and were immobilized for 5 weeks (range 2-10 weeks). With a previously tested non-invasive measuring device, we weekly assessed peak torques and rates of force development and relaxation of patients' ankle dorsiflexor contractile responses, induced via peroneal nerve stimulation. Subsequently, we derived each patient's time course of observed progressive weakness and/or recovery. RESULTS: During their critical illnesses, seven out of eight patients elicited significant decreases in measured peak torques. In survivors (n = 6) during their recovery periods, torques gradually recovered. In the two patients who died, their strengths decreased continuously until death. The rate of force development data elicited similar trends as peak torque responses, whereas relative relaxation rates differed more widely between individuals. CONCLUSION: This approach of non-invasive-stimulated muscle force assessment can be used in long-term critically ill patients and may eventually become a standard in the intensive care unit, e.g. for assessing recovery. This method is easy to employ, reproducible, provides important phenotypic quantification of skeletal muscle contractile function, and can be used for long-term outcomes assessment.
Authors:
H F Ginz; P A Iaizzo; Albert Urwyler; H Pargger
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2007-08-20
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  52     ISSN:  1399-6576     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia and Research, University of Basel, Loerrach, Germany. ginz.hans-friedrich@klinloe.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Convalescence
Critical Care / methods*,  standards
Critical Illness*
Disease Progression
Electrodiagnosis / methods*
Feasibility Studies
Female
Humans
Intensive Care / standards
Male
Middle Aged
Muscle Relaxation / physiology
Muscle Strength*
Muscle Strength Dynamometer
Muscle Weakness / diagnosis,  etiology,  physiopathology
Muscle, Skeletal / innervation,  physiopathology*
Peroneal Nerve / physiopathology*
Polyneuropathies / complications,  diagnosis*,  physiopathology
Positive-Pressure Respiration
Predictive Value of Tests
Torque
Treatment Outcome
Comments/Corrections
Comment In:
Acta Anaesthesiol Scand. 2008 Jan;52(1):1-2   [PMID:  18173429 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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