Document Detail

Use of nitric-oxide-eluting polymer-coated coronary stents for prevention of restenosis in pigs.
MedLine Citation:
PMID:  10860179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Restenosis after angioplasty remains an unresolved problem despite an increase in use of coronary stents. It has been theorized that nitric oxide (NO) exerts several actions that can prevent restenosis. These include inhibition of proliferation of smooth muscle cells, prevention of arterial spasms, and decreasing aggregation of platelets in response to exposure to collagen. OBJECTIVE: To determine whether NO coated stents decrease restenosis in a pig balloon injury model. METHODS: We used coronary stents impregnated with a slow-release precursor of NO in the porcine model of restenosis. Tantalum coil coronary stents (Cordis) were coated with a polymer impregnated with a slow-release precursor of NO. Polymer-coated stents without active precursors were used as controls. Oversized stents were mounted on a delivery balloon and subsequently deployed in the right coronary and left anterior descending arteries of each animal. RESULTS: Repeated recording of angiograms demonstrated that changes in minimum lumen diameter on going from immediately after stenting to 28-day follow-up for the control and NO-eluting-stent groups were similar, namely decreases of 1.89 +/- 0.33 and 2.08 +/- 0.28 mm, respectively. The morphometric results, showing that severe luminal narrowing occurred for both groups, were similar. The percentage area stenoses were 85 +/- 5% for the control group and 84 +/- 6% for the NO-eluting group. Histology demonstrated that profuse formation of neointima and an inflammatory cell infiltrate occurred. CONCLUSIONS: Severe diameter stenosis occurred both for control and for treatment groups. The degree of angiographic stenosis was markedly worse than that previously reported for this model. Sustained release of a precursor of NO did not prevent restenosis in this model. This might have been due to a lack of efficacy of nitric oxide or to a profuse and overwhelming stimulatory effect of the polymer in the coated stents.
J M Buergler; F O Tio; D G Schulz; M M Khan; W Mazur; B A French; A E Raizner; N M Ali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  11     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Coated Materials, Biocompatible
Coronary Disease / therapy*
Nitric Oxide / therapeutic use*
Recurrence / prevention & control
Swine, Miniature
Reg. No./Substance:
0/Coated Materials, Biocompatible; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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