Document Detail

Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden.
MedLine Citation:
PMID:  11665336     Owner:  NLM     Status:  MEDLINE    
Folic acid is recommended to reduce the risk of neural tube defects and other congenital malformations. Data from the Swedish Medical Birth Registry were used to study frequency of twinning in women who in early pregnancy reported the use of folic acid. Women (n = 2,569) who in early pregnancy reported the use of folic acid had an increased rate of twin deliveries after consideration of maternal age and of length of involuntary childlessness, both variables being significant confounders. The effect of folic acid was seen also in women who did not report involuntary childlessness. A similar but not statistically significant trend was seen after use of multivitamins without simultaneous use of folic acid tablets (n = 1,979). The increased risk seems to be limited to dizygotic twinning (relative risk = 2.13, 95% CI 1.64-2.74). If this association is causal, wide-spread supplementation with folic acid may represent a hazard larger than the postulated beneficial effect on neural tube defects, at least in low-risk areas.
A Ericson; B Källén; A Aberg
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Twin research : the official journal of the International Society for Twin Studies     Volume:  4     ISSN:  1369-0523     ISO Abbreviation:  Twin Res     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-10-22     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9815819     Medline TA:  Twin Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Epidemiological Centre, National Board of Health, Stockholm, Sweden.
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MeSH Terms
Confounding Factors (Epidemiology)
Dietary Supplements / adverse effects*
Folic Acid / adverse effects*
Maternal Age
Neural Tube Defects / prevention & control
Odds Ratio
Pregnancy Trimester, First / drug effects
Prospective Studies
Sweden / epidemiology
Twins / statistics & numerical data*
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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