| Use of the multi-organ dysfunction score as a tool to discriminate different levels of severity in uncomplicated Plasmodium falciparum malaria. | |
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MedLine Citation:
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PMID: 12685647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The usual criteria for severe malaria are not always sufficient to identify patients who subsequently develop this disease. The multi-organ dysfunction score (MODS) was assessed in 22 patients with uncomplicated Plasmodium falciparum malaria to test its usefulness in discriminating different severity levels. The MODS on admission was highly correlated with the baseline concentration of tumor necrosis factor--alpha (r = 0.83, P < 0.001) and the duration of symptoms after admission (r = 0.54, P = 0.01). The MODS was also correlated with parasite count (r = 0.52, P = 0.014), parasite clearance time (r = 0.54, P = 0.009), and fever clearance time (r = 0.58, P = 0.005). The above correlations remained significant after controlling for the initial parasitemia (P = 0.03 and 0.005). The MODS is simple and easy to apply and needs a recording time of less than three minutes. Thus, this score might provide a quantitative approach for determining severity in Plasmodium falciparum malaria. |
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Authors:
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R Helbok; W Dent; M Nacher; S Treeprasertsuk; S Krudsood; P Wilairatana; U Silachamroon; S Looareesuwan; E Schmutzhard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 68 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-04-10 Completed Date: 2003-05-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 372-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Innsbruck, Innsbruck, Austria. raimund_helbok@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antimalarials / therapeutic use Female Humans Malaria, Falciparum / drug therapy, physiopathology* Male Multiple Organ Failure / physiopathology* Severity of Illness Index* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI-51310/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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