Document Detail

Use of a mucolytic agent (Cytoclair) in the preparation of cell material for the detection of malignant cells in sputum.
MedLine Citation:
PMID:  670414     Owner:  NLM     Status:  MEDLINE    
A mucolytic agent, methyl cysteine HC1 (Cytoclair), has been used to obtain a centrifuged cell deposit for the detection of malignant cells in sputum. In 178 sputum samples from 52 patients with primary lung cancer there was a slightly higher rate of detection with the mucolytic method than with the routine method: 54 positives from 27 patients compared with 48 positives from 24 patients. Morphological studies using the mucolytic agent indicated that a millipore filter with fixation of cells in suspension produces a satisfactory cell preparation and is valuable in certain problem cases.
J M Grainger; O A Husain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  31     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-30     Completed Date:  1978-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  585-90     Citation Subset:  AIM; IM    
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MeSH Terms
Cysteine / analogs & derivatives*,  diagnostic use
Expectorants / diagnostic use*
Lung Neoplasms / diagnosis*,  pathology
Sputum / cytology*
Reg. No./Substance:
0/Expectorants; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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