Document Detail

Use of the mitral valve-tricuspid valve distance as a marker of fetal endocardial cushion defects.
MedLine Citation:
PMID:  15507987     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to compare the mitral valve-tricuspid valve distance in second-trimester fetuses with normal cardiac anatomy versus those fetuses with endocardial cushion defects. STUDY DESIGN: We identified fetuses between 16 and 24 weeks of gestation. The distance between the insertions of the medial leaflets of the mitral and tricuspid valves were obtained. Linear regression curves were generated. RESULTS: The mean mitral valve-tricuspid valve distance for 86 fetuses with normal cardiac anatomy was 2.02 mm, compared with 0.37 mm in 13 fetuses with endocardial cushion defects ( P = .0001). Linear regression curve correlating mitral valve-tricuspid valve distance with gestational age showed a gradual slope (R 2 = 0.28; P < .0001). With a mitral valve-tricuspid valve distance < 5th percentile as a marker for the diagnosis of endocardial cushion defect gave a sensitivity of 69.2%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 95.6%, and a false-positive rate of 0% ( P = .0001). CONCLUSION: The mitral valve-tricuspid valve distance is useful clinically in the detection of endocardial cushion defects in second-trimester fetuses.
Alan D Bolnick; Carolyn M Zelop; Beth Milewski; Elisa A Gianferrari; Adam F Borgida; James F X Egan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-27     Completed Date:  2004-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1483-5     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, Division of Maternal-Fetal Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
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MeSH Terms
Endocardial Cushion Defects / ultrasonography*
Fetal Diseases / ultrasonography*
Gestational Age
Mitral Valve / pathology,  ultrasonography*
Retrospective Studies
Sensitivity and Specificity
Tricuspid Valve / pathology,  ultrasonography*
Ultrasonography, Prenatal*

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