| Use of mitomycin C for treatment of keloid: a preliminary report. | |
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MedLine Citation:
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PMID: 15806053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision. STUDY DESIGN AND SETTING: Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed. RESULTS: All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm. CONCLUSIONS: MC application following scar resection appears to be effective in treatment of keloid. SIGNIFICANCE: As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome. |
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Authors:
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Yoav P Talmi; Arie Orenstein; Michael Wolf; Jona Kronenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 132 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-04 Completed Date: 2005-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 598-601 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology--Head and Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel. yoav.talmi@sheba.health.gov.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibiotics, Antineoplastic / administration & dosage*, adverse effects Chemotherapy, Adjuvant Combined Modality Therapy Female Humans Keloid / drug therapy*, surgery Male Middle Aged Mitomycin / administration & dosage*, adverse effects Nucleic Acid Synthesis Inhibitors / administration & dosage*, adverse effects Otorhinolaryngologic Diseases / drug therapy*, surgery Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Nucleic Acid Synthesis Inhibitors; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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