Document Detail


Use of mitomycin C for treatment of keloid: a preliminary report.
MedLine Citation:
PMID:  15806053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Mitomycin C (MC) is an anti-neoplastic agent with an anti-proliferative effect on fibroblasts. We set out to evaluate the effect of MC application following keloid excision. STUDY DESIGN AND SETTING: Patients with keloid in a tertiary referral center were enrolled in a prospective study. The scar was excised and prior to skin closure, a pledget with 1 cc of MC 0.4 mg/mL was applied for 5 minutes. Patient satisfaction and keloid thickness were assessed. RESULTS: All patients were satisfied with the results, although complete disappearance of the keloid was evident only in two. Keloid thickness was measured and ranged from 5 to 26 mm. Following surgery and treatment at 2 months thickness ranged from 0 to 8 mm. CONCLUSIONS: MC application following scar resection appears to be effective in treatment of keloid. SIGNIFICANCE: As no specific effective treatment for keloid is currently available, utilization of this readily available therapeutic agent may improve treatment outcome.
Authors:
Yoav P Talmi; Arie Orenstein; Michael Wolf; Jona Kronenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  132     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  598-601     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology--Head and Neck Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel. yoav.talmi@sheba.health.gov.il
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibiotics, Antineoplastic / administration & dosage*,  adverse effects
Chemotherapy, Adjuvant
Combined Modality Therapy
Female
Humans
Keloid / drug therapy*,  surgery
Male
Middle Aged
Mitomycin / administration & dosage*,  adverse effects
Nucleic Acid Synthesis Inhibitors / administration & dosage*,  adverse effects
Otorhinolaryngologic Diseases / drug therapy*,  surgery
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Nucleic Acid Synthesis Inhibitors; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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