Document Detail

Use of misoprostol on an outpatient basis for postdate pregnancy.
MedLine Citation:
PMID:  15694083     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Within the obstetric community, several studies suggest that cervical ripening and labor induction after 40 weeks' gestation leads to improved maternal and neonatal outcomes. The most effective drug regimen to safely promote labor has not been determined. METHOD: Forty-nine subjects followed in an outpatient obstetrical clinic with pregnancies of at least 40 weeks' gestation, and an unfavorable Bishop score were assigned randomly to receive oral misoprostol 50 or 25 microg every 3 days for a maximum of three doses. RESULTS: Twenty-three subjects received misoprostol 25 microg and 26 received 50 microg. The mean interval (+/-standard deviation) from start of cervical ripening to delivery was 2.4 days +/-0.3 vs. 3.9 days +/-0.7 for the 50 and 25 microg groups (P<0.05). No adverse events were noted. However, due to small sample size, less frequent adverse events may be missed. Type II errors cannot be excluded. CONCLUSION: In the prevention of postdate pregnancy, outpatients use of oral misoprostol 50 microg appears to result in earlier delivery, as compared to 25 microg.
J H Kipikasa; C D Adair; J Williamson; J M Breen; L K Medford; L Sanchez-Ramos
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2004-12-28
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  88     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  108-11     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, The University of Tennessee College of Medicine, Chattanooga Unit, Chattanooga, TN, USA.
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MeSH Terms
Ambulatory Care
Cervical Ripening / drug effects*
Dose-Response Relationship, Drug
Misoprostol / administration & dosage*
Pregnancy, Prolonged
Reg. No./Substance:
0/Oxytocics; 59122-46-2/Misoprostol

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