Document Detail

Use of misoprostol for cervical ripening.
MedLine Citation:
PMID:  11005347     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Misoprostol, the prostaglandin E1 analog, is increasingly used for cervical ripening and induction of labor. We evaluated our experience with misoprostol in an open-label setting. METHODS: Patients were selected for cervical ripening based on clinical profile. At 3 cm cervical dilation, misoprostol was discontinued and other means of labor augmentation were used. Over 13 months, 470 inductions of labor occurred, and 455 charts were available; 254 patients (56%) received misoprostol for cervical ripening, and 144 (32%) received dinoprostone (prostaglandin E2). RESULTS: With misoprostol, mean time from beginning of contractions until delivery was 7 hours, 30 minutes; vaginal birth occurred in 85% of cases, and spontaneous labor occurred in 38%. Hyperstimulation occurred in 4 cases (1.6%) and precipitate labor in 7 (3%). All infants were discharged in excellent condition; one had a 5-minute Apgar score <7, and 33 (13%) had meconium, none with aspiration. Twenty-three patients who had had a previous cesarean section received misoprostol and delivered vaginally. CONCLUSION: Misoprostol was found to be a safe and effective agent for cervical ripening as part of labor induction.
V L Katz; R M Farmer; C A Dean; M E Carpenter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  93     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  881-4     Citation Subset:  AIM; IM    
Sacred Heart Medical Center, Eugene, Ore, USA.
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MeSH Terms
Apgar Score
Cervical Ripening / drug effects*
Cervix Uteri / drug effects
Delivery, Obstetric
Dinoprostone / adverse effects,  therapeutic use
Fetal Distress / chemically induced
Infant, Newborn
Labor, Induced / methods
Labor, Obstetric / drug effects
Misoprostol / adverse effects,  therapeutic use*
Oxytocics / adverse effects,  therapeutic use*
Oxytocin / adverse effects,  therapeutic use
Pregnancy Outcome
Retrospective Studies
Time Factors
Treatment Outcome
Uterine Contraction / drug effects
Vaginal Birth after Cesarean
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 50-56-6/Oxytocin; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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