Document Detail


Use of microwave in processing of drug delivery systems.
MedLine Citation:
PMID:  18393808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microwave has received a widespread application in pharmaceuticals and food processing, microbial sterilization, biomedical therapy, scientific and biomedical analysis, as well as, drug synthesis. This paper reviews the basis of application of microwave to prepare pharmaceutical dosage forms such as agglomerates, gel beads, microspheres, nanomatrix, solid dispersion, tablets and film coat. The microwave could induce drying, polymeric crosslinkages as well as drug-polymer interaction, and modify the structure of drug crystallites via its effects of heating and/or electromagnetic field on the dosage forms. The use of microwave opens a new approach to control the physicochemical properties and drug delivery profiles of pharmaceutical dosage forms without the need for excessive heat, lengthy process or toxic reactants. Alternatively, the microwave can be utilized to process excipients prior to their use in the formulation of drug delivery systems. The intended release characteristics of drugs in dosage forms can be met through modifying the physicochemical properties of excipients using the microwave.
Authors:
T W Wong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug delivery     Volume:  5     ISSN:  1567-2018     ISO Abbreviation:  -     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208455     Medline TA:  Curr Drug Deliv     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia. wongtinwui@salam.uitm.edu.my
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical / methods
Dosage Forms
Excipients / chemistry
Microwaves*
Pharmaceutical Preparations / administration & dosage,  chemistry*
Technology, Pharmaceutical / methods*
Chemical
Reg. No./Substance:
0/Dosage Forms; 0/Excipients; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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