Document Detail


Use of metzler's NONLIN program for fitting discontinuous absorption profiles.
MedLine Citation:
PMID:  6687609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An alternative to the use of integral hybrid flow/compartmental model (HFCM) equations in fitting cases I and II discontinuous absorption profiles is presented. It is proposed that HFCM-integral equations be replaced by a system of differential equations in which sequential sets of equations describe the absorption profile from time zero to infinity. The required sets of differential equations for these two cases are presented as they apply to a two-compartment drug, potentially undergoing multiple absorption steps. It was shown that the use of the NONLIN program in the differential equation mode provides good fits for some unusually shaped absorption profiles of buformin, sulfisoxazole, and griseofulvin. The values of the parameter estimates and the sum of squared deviations, sigma SD, obtained with NONLIN were almost identical to those obtained with the FITS12 program utilizing HFCM equations. While HFCM-integral equations required less computer time, they introduced the potential for negative absorption times. This problem is avoided by use of the differential equations method.
Authors:
J J Zimmerman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  72     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  138-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption*
Buformin / metabolism
Griseofulvin / metabolism
Humans
Kinetics
Models, Biological
Pharmaceutical Preparations / metabolism*
Software
Sulfisoxazole / metabolism
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; 126-07-8/Griseofulvin; 127-69-5/Sulfisoxazole; 692-13-7/Buformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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