Document Detail

Use of metoprolol in dogs with acquired cardiac disease.
MedLine Citation:
PMID:  19081348     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To evaluate the response to metoprolol in dogs with dilated cardiomyopathy or endocardiosis receiving standard therapies for management of heart disease.
BACKGROUND: Beta-blocker therapy has been documented to improve survival in human patients with heart disease and heart failure. There are few studies documenting the effects of beta-blockers in dogs with naturally occurring heart disease.
METHODS: A retrospective study of medical records of dogs treated with metoprolol between 1991 and May 2000.
RESULTS: Eighty-seven dogs were treated with metoprolol between 1991 and May 2000. The majority of dogs tolerated the addition of metoprolol in a step-wise fashion. Side effects included syncope, congestive heart failure, lethargy, anorexia, weakness and diarrhea. Side effects were not more likely in dogs with pre-existing congestive heart failure.
CONCLUSIONS: Metoprolol was well tolerated in the majority of dogs with naturally occurring dilated cardiomyopathy or endocardiosis. Further studies are required to determine if the administration of metoprolol is beneficial for this patient population.
John E Rush; Lisa M Freeman; Cari Hiler; Donald J Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology     Volume:  4     ISSN:  1875-0834     ISO Abbreviation:  J Vet Cardiol     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101163270     Medline TA:  J Vet Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  -    
Department of Clinical Sciences, Tufts University School of Veterinary Medicine. Dr. Hiler's current address is Neponset Pet Center, Dorchester, MA.
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