| Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. | |
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MedLine Citation:
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PMID: 12693777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methylphenidate is commonly believed to lower seizure threshold. The safe use of methylphenidate has not been clarified in patients with attention-deficit hyperactivity disorder (ADHD) and concomitant active seizure or electroencephalographic (EEG) abnormalities. Patients with ADHD and active seizures (n = 57) and patients with ADHD and EEG abnormalities (n = 62), 6 to 16 years of age, were included in the study. The safety and efficacy of treatment with antiepilepsy drugs combined with methylphenidate were determined by assessing seizure frequency, changes in ADHD symptoms, the Conners' Rating Scales, EEG differences, and side effects. The Conners' Rating Scales, performed by parents and teachers, and mean total ADHD symptom scores at the beginning of the study and at the end were significantly different (P = .05 for the Conners' Rating Scales and P = .001 for ADHD symptom scores). Methylphenidate had a beneficial effect on EEG. Seizure frequency did not change from baseline. The side effects of methylphenidate were mild and transient Methylphenidate is safe and effective in children with ADHD and concomitant active seizures or EEG abnormalities. |
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Authors:
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Kivilcim Gucuyener; A Kemal Erdemoglu; Selahattin Senol; Ayşe Serdaroglu; Sebnem Soysal; A Ilden Kockar |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 18 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-04-15 Completed Date: 2003-05-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 109-12 Citation Subset: IM |
Affiliation:
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Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anticonvulsants / administration & dosage, pharmacology Attention Deficit Disorder with Hyperactivity / complications*, drug therapy* Central Nervous System Stimulants / pharmacology* Child Comorbidity Electroencephalography Epilepsy / complications*, drug therapy* Female Humans Male Methylphenidate / pharmacology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Central Nervous System Stimulants; 113-45-1/Methylphenidate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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