| Use of methylene blue in patients with refractory septic shock: impact on hemodynamics and gas exchange. | |
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MedLine Citation:
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PMID: 9869542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to assess the acute effects of methylene blue, an inhibitor of nitric oxide synthesis, on hemodynamics and gas exchange in patients with refractory septic shock in a prospective clinical trial at medical and surgical intensive care units in a tertiary university hospital. PATIENTS AND METHODS: Prospective, sequential study of 10 consecutive patients admitted with severe septic shock of diverse causes and unable to achieve an adequate arterial pressure despite the use of at least two vasoactive drugs. Six of them also developed acute lung injury. All received 1 mg/kg intravenous bolus of methylene blue. Hemodynamic and respiratory parameters were measured at baseline and at 30, 60, 120, and 180 minutes after the bolus injection. RESULTS: Systolic, diastolic, mean arterial blood pressure, and systemic vascular resistance increased significantly in all patients, whereas no significant changes were observed in cardiac output, oxygen consumption, or oxygen extraction ratio. Gas exchange remained unaffected in patients with acute lung injury. CONCLUSIONS: Methylene blue had an acute vasopressor effect in patients with refractory septic shock, and it was not deleterious on respiratory function. |
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Authors:
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M Andresen; A Dougnac; O Díaz; G Hernández; L Castillo; G Bugedo; M Alvarez; J Dagnino |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of critical care Volume: 13 ISSN: 0883-9441 ISO Abbreviation: J Crit Care Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-03 Completed Date: 1999-03-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 164-8 Citation Subset: IM |
Affiliation:
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Medical Intensive Care Unit, Hospital ClinicoPontificia Universidad Catolica de Chile, Santiago. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Hemodynamics / drug effects* Humans Injections, Intravenous Male Methylene Blue / therapeutic use* Middle Aged Nitric Oxide / antagonists & inhibitors* Prospective Studies Pulmonary Gas Exchange / drug effects* Respiratory Distress Syndrome, Adult / complications, drug therapy Shock, Septic / complications, drug therapy*, immunology, physiopathology Time Factors |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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