Document Detail

Use of methotrexate in patients with sarcoidosis.
MedLine Citation:
PMID:  21044457     Owner:  NLM     Status:  MEDLINE    
Sarcoidosis may present with symptoms related to involvement of joints, skin and lungs, as well as other organs. Corticosteroids are the basis of treatment of symptomatic sarcoidosis. Additional or alternative drugs may be required in chronic cases and when systemic corticosteroids are contraindicated. Cytotoxic agents seem to be of value in selected patients, but no controlled studies are available, and the published literature consists of small case series. Therefore, no international agreement exists regarding when these drugs should be used in patients with sarcoidosis. Methotrexate is generally the preferred agent for treatment of chronic sarcoidosis when corticosteroids have inadequate efficacy and/or severe adverse effects. In this review we discuss the available literature concerning the treatment of sarcoidosis with methotrexate.
U Kiltz; J Braun
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-28
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  28     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S183-5     Citation Subset:  IM    
Rheumazentrum Ruhrgebiet, Herne, Germany.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents / therapeutic use*
Chronic Disease
Evidence-Based Medicine
Methotrexate / therapeutic use*
Sarcoidosis / drug therapy*
Sarcoidosis, Pulmonary / drug therapy
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents; 59-05-2/Methotrexate

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