| Use of methadone in the morphine-tolerant burned paediatric patient. | |
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MedLine Citation:
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PMID: 9505787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the successful use of methadone in the restoration of sedation and provision of analgesia in two morphine-tolerant, paediatric patients who had suffered significant thermal injuries and were undergoing mechanical ventilation. Both patients had exhibited escalating requirements for sedative drugs while undergoing ventilation yet remained inadequately sedated. The introduction of i.v. methadone in place of i.v. morphine in the sedative regimen rapidly and effectively restored a state of sedation. Hyperalgesia and morphine tolerance appear to be associated; it is proposed that methadone acts primarily, under these circumstances, by re-establishing the analgesic state. Such use of methadone in the morphine-tolerant patient also afforded a concomitant sedative-sparing effect. |
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Authors:
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P I Williams; R E Sarginson; J M Ratcliffe |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 80 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-24 Completed Date: 1998-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 92-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Ormskirk and District General Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid* Burns / therapy* Child Conscious Sedation / methods* Drug Tolerance Female Humans Infant Intensive Care / methods* Methadone* Morphine Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 57-27-2/Morphine; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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