Document Detail

Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.
MedLine Citation:
PMID:  16895631     Owner:  NLM     Status:  MEDLINE    
In the present study, which includes 287 participants, metformin has been used by women undergoing IVF/intracytoplasmic sperm injection for more than 5 weeks before and during treatment and during luteal phase. There was no significant difference in number of gonadotrophins used, days of stimulation, number of oocytes retrieved, and number of embryos replaced. There was no significant difference in clinical pregnancy rate between both groups but there was significant reduction in the incidence of ovarian hyperstimulation syndrome (OHSS) in the group taking metformin. Metformin is a safe, cheap drug that can help in prevention of OHSS.
Sherif Khattab; Ismail Aboul Fotouh; Iman Abdel Mohesn; Mostapha Metwally; Mohamed Moaz
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  13     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-09     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  194-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Cairo University, Misr International Hospital, 40, Abdel Rehim Sabry St, Dokki, Cairo, Egypt.
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MeSH Terms
Drug Therapy, Combination
Embryo Transfer
Estrogens / blood
Follicle Stimulating Hormone / therapeutic use
Iatrogenic Disease / prevention & control*
Infertility, Female / drug therapy
Metformin / therapeutic use*
Oocytes / drug effects
Ovarian Hyperstimulation Syndrome / prevention & control*
Ovulation Induction / adverse effects
Pregnancy Rate
Sperm Injections, Intracytoplasmic / adverse effects
Reg. No./Substance:
0/Estrogens; 657-24-9/Metformin; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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