| Use of medication during pregnancy and risk of childhood leukemia (Canada). | |
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MedLine Citation:
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PMID: 15577295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine risk of childhood acute lymphoblastic leukemia (ALL) associated with maternal use of medications during pregnancy; in particular medications known or suspected to be teratogenic. METHODS: Seven hundred and eighty nine children (< 15 years old) diagnosed with ALL in the province of Quebec between 1980 and 2000 were recruited for study. A similar number of population based controls matched to cases (1:1) by sex and age were chosen from family allowance or health insurance files. Information was gathered via telephone interview with the subjects' parents. Data were analyzed using conditional logistic regression. RESULTS: Risk of childhood ALL was significantly increased in the offspring of mothers who reported using any medication (adjusted odds ratio (OR(adj)) = 1.3, 95% CI = 1.0-1.6) or any teratogenic medication (OR(adj) = 1.4, 95% CI = 1.1-1.9) during pregnancy. Among specific medication categories, only central nervous system depressants were associated with a significantly increased risk, although elevated odd ratios were found for anti-epileptics, immunosuppressants, oral contraceptives, and illicit drugs. Risk associated with use of teratogenic medications was higher with increased dose and in children diagnosed before two years of age. CONCLUSION: A modest increase in risk of ALL was found among children of mothers who used medication during pregnancy. |
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Authors:
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Amanda K Shaw; Claire Infante-Rivard; Howard I Morrison |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 15 ISSN: 0957-5243 ISO Abbreviation: Cancer Causes Control Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-12-03 Completed Date: 2005-04-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: Netherlands |
Other Details:
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Languages: eng Pagination: 931-7 Citation Subset: IM |
Affiliation:
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Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Canada / epidemiology Case-Control Studies Child Child, Preschool Dose-Response Relationship, Drug Female Humans Infant Infant, Newborn Interviews as Topic Male Maternal Exposure / adverse effects* Pharmaceutical Preparations / administration & dosage, adverse effects* Precursor Cell Lymphoblastic Leukemia-Lymphoma / chemically induced*, epidemiology* Pregnancy Prenatal Exposure Delayed Effects* Risk Factors Teratogens |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 0/Teratogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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