| Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products. | |
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MedLine Citation:
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PMID: 11834465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disinfection by-products (DBPs) are formed when disinfectants such as chlorine, chloramine, and ozone react with organic and inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over the possible adverse health effects of DBPs. To date, several hundred DBPs have been identified. To prioritize research efforts, an in-depth, mechanism-based structure-activity relationship analysis, supplemented by extensive literature search for genotoxicity and other data, was conducted for ranking the carcinogenic potential of DBPs that met the following criteria: a) detected in actual drinking water samples, b) have insufficient cancer bioassay data for risk assessment, and c) have structural features/alerts or short-term predictive assays indicative of carcinogenic potential. A semiquantitative concern rating scale of low, marginal, low-moderate, moderate, high-moderate, and high was used along with delineation of scientific rationale. Of the 209 DBPs analyzed, 20 were of priority concern with a moderate or high-moderate rating. Of these, four were structural analogs of MX and five were haloalkanes that presumably will be controlled by existing and future THM regulations. The other eleven DBPs, which included halonitriles (6), haloketones (2), haloaldehyde (1), halonitroalkane (1), and dialdehyde (1), are suitable priority candidates for future carcinogenicity testing and/or mechanistic studies. |
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Authors:
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Yin-Tak Woo; David Lai; Jennifer L McLain; Mary Ko Manibusan; Vicki Dellarco |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Environmental health perspectives Volume: 110 Suppl 1 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-03-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: United States |
Other Details:
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Languages: eng Pagination: 75-87 Citation Subset: IM |
Affiliation:
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Office of Prevention, Pesticides, and Toxic Substances, Risk Assessment Division, U.S. Environmental Protection Agency, Washington, DC, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Laboratory Biological Assay Carcinogens / adverse effects* Chlorine Compounds / adverse effects DNA Damage Disinfectants / adverse effects*, chemistry Humans Mutagenicity Tests Risk Assessment Structure-Activity Relationship Trihalomethanes / adverse effects Water Purification Water Supply* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Chlorine Compounds; 0/Disinfectants; 0/Trihalomethanes |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 2 Year: 2002 Volume: 110 Issue: Suppl 1 First Page: 75 Last Page: 87 ID: 1241149 PubMed Id: 11834465 Publisher Item Identifier: sc271_5_1835 |
| Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products. | |
| Yin-Tak Woo | |
| David Lai | |
| Jennifer L McLain | |
| Mary Ko Manibusan | |
| Vicki Dellarco | |
| Office of Prevention, Pesticides, and Toxic Substances, Risk Assessment Division, U.S. Environmental Protection Agency, Washington, DC, USA. |
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