Document Detail


Use of a mathematical model to estimate stress and strain during elevated pressure induced lamina cribrosa deformation.
MedLine Citation:
PMID:  11803484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: High intraocular pressure (IOP), which is generally associated with glaucoma, causes lamina cribrosa retrodisplacement and deformation. Shear stress and strain resulting from lamina cribrosa deformation have been implicated in tissue remodeling, changes in retinal astrocyte function and retinal ganglion cell (RGC) death observed in vivo during glaucoma. METHODS: A mathematical model was developed to describe the lamina cribrosa exposed to elevated intraocular pressure (IOP). The model is based on the bending theory of plates, incorporates anatomical properties of the lamina cribrosa, and provides estimates of its biomechanical properties. The model relates IOP, the parameter normally correlated with glaucoma, and lamina cribrosa retrodisplacement to stress and strain experienced by cells, parameters that may be more closely associated with cell injury. RESULTS: We estimate that shear strains of 0.05 occur at the edge of a 200 microm thick lamina cribrosa at an IOP of 25 mm Hg. We estimate greater lamina cribrosa deformation and higher shear stress and strain for thinner lamina cribrosa and lamina cribrosa of larger radii. CONCLUSION: These results may provide better estimates of the stress and strain experienced by cells in the lamina cribrosa and may further our understanding of the forces that contribute to optic nerve degeneration during glaucoma.
Authors:
M E Edwards; T A Good
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  23     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-01-22     Completed Date:  2002-03-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  215-25     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, Texas A&M University, College Station, TX 77943-3122, USA.
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MeSH Terms
Descriptor/Qualifier:
Biomechanics
Glaucoma / etiology,  physiopathology*
Humans
Intraocular Pressure*
Models, Biological
Models, Theoretical
Ocular Hypertension / complications,  physiopathology*
Optic Disk / physiopathology*
Optic Nerve Diseases / etiology,  physiopathology*
Stress, Physiological / complications,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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