| Use of a magnetic sphincter for the treatment of GERD: a feasibility study. | |
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MedLine Citation:
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PMID: 18226691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The success of fundoplication surgery varies widely; furthermore, complications after fundoplication can be common. We introduced a new device to treat GERD: biomechanical augmentation of the lower esophageal sphincter (LES) by use of a magnetic reinforcing appliance. OBJECTIVES: The aim was to determine whether a magnetic appliance could safely increase LES pressure, maintain a closed sphincter except during swallowing and belching, and increase the gastric yield pressure in a porcine model. DESIGN: Ex vivo work-assessed design variables that would augment the reflux barrier yet still preserve swallow function. Porcine acute and chronic (44 weeks) postimplant studies were also performed. A single animal underwent planned device removal. MAIN OUTCOME MEASUREMENTS: Gastric yield pressure, animal behavior, endoscopy, barium studies, balloon expansion studies, esophageal manometry, and histology. RESULTS: Gastric yield pressure correlated with increasing magnetic forces (R(2)=0.5608, P< .001). The sphincter augmentation device was safe in all animals, with no observed effect on eating behavior and normal weight gain. The mucosa of the esophagus appeared normal at all intervals, and there was no device migration or significant tissue inflammation. The average LES pressure rose after implantation (P< .005). Balloon and barium studies demonstrated a closed sphincter with normal opening of the gastroesophageal junction during swallowing. CONCLUSIONS: Magnetic sphincter augmentation is a novel approach for the treatment of GERD. This study demonstrates the safety and feasibility of such a device in a porcine model. Further investigation of this device for the treatment of GERD in humans seems warranted. |
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Authors:
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Robert A Ganz; Christopher J Gostout; Jerry Grudem; William Swanson; Todd Berg; Tom R DeMeester |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastrointestinal endoscopy Volume: 67 ISSN: 0016-5107 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-29 Completed Date: 2008-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: IM |
Affiliation:
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Minnesota Gastroenterology, Plymouth, Minnesota 55446, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Equipment Design Esophageal Sphincter, Lower* Feasibility Studies Gastroesophageal Reflux / surgery* Magnetics* Male Pressure Prostheses and Implants* Swine |
| Comments/Corrections | |
Comment In:
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Gastrointest Endosc. 2008 Feb;67(2):295-6
[PMID:
18226692
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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