Document Detail

Use of low dose dopamine, gabexate mesilate and ulinastatin reduces the water balance and pulmonary complication in thoracic esophagectomy patients.
MedLine Citation:
PMID:  16045575     Owner:  NLM     Status:  MEDLINE    
In spite of improvements in surgical technique and perioperative care, severe lung complication remains as the leading cause of morbidity in thoracic esophageal cancer patients who undergo esophagectomy. The purpose of this study was to evaluate the safety and effectiveness of postoperative drug therapy using low dose dopamine, gabexate mesilate, and ulinastatin on postoperative lung complication in esophageal cancer patients. Sixty-one patients operated for esophageal cancer from 1996 to 2000 were treated postoperatively with low dose dopamine (300 microg/kg/h), gabexate mesilate (80 mg/h), and ulinastatin (300 000 unit/day) as a study group. Seventy-four patients operated from 1987 to 1994 served as an historical control group. Various preoperative and perioperative medical parameters and water balance were analyzed. Postoperative pulmonary complications were observed in 26 patients (35.1%) in the control group and three patients (4.9%) in the study group, respectively (P < 0.0001). Preoperative and perioperative variables were not significantly different between the groups. Water balance from operation to postoperative day 3 in the study group was significantly lower than the control group. Postoperative use of low dose dopamine, gabexate mesilate, and ulinastatin significantly reduced pulmonary complications after esophagectomy. This may be partly attributable to negative water balance during the early postoperative days.
A Sato; Y Kuwabara; N Shinoda; M Kimura; H Ishiguro; Y Fujii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  18     ISSN:  1120-8694     ISO Abbreviation:  Dis. Esophagus     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-12-20     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / surgery*
Dopamine / therapeutic use
Esophageal Neoplasms / surgery*
Esophagectomy / adverse effects*
Gabexate / therapeutic use
Glycoproteins / therapeutic use
Lung Diseases / etiology*,  prevention & control
Middle Aged
Renal Agents / therapeutic use
Serine Proteinase Inhibitors / therapeutic use
Thoracotomy / adverse effects*
Treatment Outcome
Water-Electrolyte Imbalance / etiology
Reg. No./Substance:
0/Glycoproteins; 0/Renal Agents; 0/Serine Proteinase Inhibitors; 39492-01-8/Gabexate; 80449-32-7/urinastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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