| Use of a lipid emulsion in a patient with refractory hypotension caused by glyphosate-surfactant herbicide. | |
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MedLine Citation:
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PMID: 20569074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Circulatory shock is a major cause of mortality in glyphosate-surfactant herbicide (GlySH) poisoning, and this condition responds poorly to conventional therapies. We report a case of GlySH poisoning with shock that was refractory to vasopressors but responsive to intravenous fat emulsion (IFE). CASE DETAILS: A 52-year-old man was brought to the emergency department by ambulance. He was found unconscious in his living room along with an empty bottle of GlySH herbicide, which contained glyphosate, polyoxyethyleneamine (POEA) surfactant, and water. He was drowsy at presentation. His heart rate was 44 beats/min, his blood pressure could not be measured with an arm cuff, but he had a palpable femoral pulse. After about 2.5 h of supportive care after admission, he remained hypotensive, and his systolic blood pressure was 80 mmHg. A 500 mL bottle of 20% IFE product was prepared. As a bolus, 100 mL of IFE was injected, and the remaining 400 mL was then infused. His blood pressure was 100/60 mmHg 1 h after the bolus injection. At 5 h after IFE injection, his blood pressure reached 160/100 mmHg and vasopressors were tapered. CONCLUSION: IFE should be considered in cases of refractory hemodynamic instability caused by GlySH after aggressive fluid and vasopressor support. |
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Authors:
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Sang Kyoon Han; Jinwoo Jeong; Seokran Yeom; Jiho Ryu; Sungwook Park |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical toxicology (Philadelphia, Pa.) Volume: 48 ISSN: 1556-9519 ISO Abbreviation: Clin Toxicol (Phila) Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241654 Medline TA: Clin Toxicol (Phila) Country: England |
Other Details:
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Languages: eng Pagination: 566-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Emergency Medicine, Pusan National University Hospital, Seo-Gu, Busan, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fat Emulsions, Intravenous
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therapeutic use* Glycine / analogs & derivatives*, poisoning Herbicides / poisoning* Humans Hypotension / chemically induced*, drug therapy Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Herbicides; 1071-83-6/glyphosate; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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