| Use of lidocaine-prilocaine cream for vaccination pain in infants. | |
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MedLine Citation:
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PMID: 8151485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether use of lidocaine-prilocaine 5% cream (EMLA) decreases pain associated with diphtheria-pertussis-tetanus (DPT) vaccination in infants. METHODS: Randomize, double-blind, controlled trial in outpatient pediatric practice, Toronto, Ontario, Canada. Before vaccination, parents applied 2.5 gm of EMLA or placebo to the infant's leg and covered it with an occlusive dressing for at least 60 minutes. The infant received a 0.5 ml intramuscular injection of DPT at 2 degree to 8 degree C with a 1.6 cm 25-gauge needle; the infant was videotaped. The Modified Behavioral Pain Scale (MBPS) was used to assess baseline and postvaccination pain scores. Latency and duration of infant cry were also measured. RESULTS: A total of 49 evaluable infants received EMLA, and 47 infants received placebo. There were no significant differences in demographic data; mean age was 5 months; and 50% of the subjects were male. The median difference in pre-vaccination and postvaccination MBPS scores was lower for EMLA than for placebo (p = 0.001). The latency to the first cry was longer for subjects who were treated with EMLA (p = 0.0004)), but the total crying time was shorter (10.3 seconds vs 25.2 seconds; p = 0.027). Of the study group, 90% (45/50) of subjects treated with EMLA and 12% (6/49) of subjects treated with placebo had local skin reactions (p < 0.0001), mainly skin blanching. CONCLUSIONS: Pretreatment with EMLA decreases infant pain from DPT vaccinations. Application of these data is limited to healthy infants receiving DPT vaccinations. |
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Authors:
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A Taddio; I Nulman; M Goldbach; M Ipp; G Koren |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 124 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-10 Completed Date: 1994-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 643-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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therapeutic use* Diphtheria-Tetanus-Pertussis Vaccine Double-Blind Method Drug Combinations Female Humans Infant Injections, Intramuscular / adverse effects Lidocaine / therapeutic use* Male Ointments Pain / etiology, prevention & control* Pain Measurement Prilocaine / therapeutic use* Regression Analysis Vaccination / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Drug Combinations; 0/EMLA; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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