Document Detail

Use of levonorgestrel-releasing intrauterine system in the prevention and treatment of endometrial hyperplasia.
MedLine Citation:
PMID:  23151756     Owner:  NLM     Status:  In-Data-Review    
Endometrial hyperplasia is a commonly seen gynecological condition that affects women of all age groups. Whereas hysterectomy is the most preferred treatment option for complex endometrial hyperplasia with atypia, there is no consensus regarding the first-line management of women with hyperplasia without cytological atypia. Oral progestogen therapy was used with some success. Nonetheless, it may be plausible to argue that women with endometrial hyperplasia need continuous treatment and high level of compliance to ensure complete regression, which may not be guaranteed with oral therapy. Observational studies suggested that levonorgestrel-releasing intrauterine system (LNG-IUS) has been successfully used to treat endometrial hyperplasia without cytological atypia and selected cases of atypical endometrial hyperplasia. Furthermore, there is strong evidence from randomized controlled trials that LNG-IUS prevents the development of endometrial hyperplasia in exogenous estrogen users; however, its protective role and safety in tamoxifen-treated breast cancer survivors remain uncertain. This article evaluates the current evidence for the use of LNG-IUS, releasing 20 μg of LNG per day, in the prevention and treatment of endometrial hyperplasia.
Ayman A A Ewies; Fadi Alfhaily
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  67     ISSN:  1533-9866     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-33     Citation Subset:  IM    
Consultant Gynecologist, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham City Hospital, Birmingham, West Midlands.
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