Document Detail

Use of lepirudin during percutaneous vascular interventions in patients with heparin-induced thrombocytopenia.
MedLine Citation:
PMID:  14608129     Owner:  NLM     Status:  MEDLINE    
METHODS: Patients undergoing PI with known diagnosis of HIT were assigned to varying doses of lepirudin, often in combination with a platelet glycoprotein (GP) IIb/IIIa inhibitor. Predetermined endpoints of safety and efficacy were assessed prospectively.
RESULTS: Twenty-five patients underwent a total of 36 interventions. Angiographic success was obtained in 100% of patients and clinical success (freedom from death, myocardial infarction, stroke or target vessel revascularization) in 92% of patients. There was 1 procedure-related mortality resulting from a retroperitoneal bleed. Three patients had minor bleeding.
CONCLUSION: Lepirudin is efficacious as a replacement for heparin in patients with HIT undergoing PI. Caution should be used when using a combination of lepirudin, GP IIb/IIIa inhibitors, clopidogrel and aspirin.
Kevin Cochran; Tony J DeMartini; Bruce E Lewis; James O Brien; Lowell H Steen; Eric D Grassman; Ferdinand Leya
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  15     ISSN:  1042-3931     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-03-12     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Loyola University Medical Center, Maywood, IL, USA.
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MeSH Terms
Angioplasty, Balloon / methods*
Antibodies, Monoclonal / therapeutic use
Anticoagulants / therapeutic use*
Drug Therapy, Combination
Heparin / adverse effects*
Hirudins / analogs & derivatives*
Immunoglobulin Fab Fragments / therapeutic use
Peptides / therapeutic use
Platelet Aggregation Inhibitors / therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex / therapeutic use
Prospective Studies
Recombinant Proteins / therapeutic use*
Thrombocytopenia / chemically induced*
Treatment Outcome
Tyrosine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Anticoagulants; 0/Hirudins; 0/Immunoglobulin Fab Fragments; 0/Peptides; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Recombinant Proteins; 0/eptifibatide; 0/lepirudin; 144494-65-5/tirofiban; 55520-40-6/Tyrosine; 9005-49-6/Heparin; X85G7936GV/abciximab
Comment In:
J Invasive Cardiol. 2003 Nov;15(11):622-3   [PMID:  14608130 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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