| Use of ketoconazole in the treatment of Cushing's disease and ectopic ACTH syndrome. | |
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MedLine Citation:
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PMID: 2004474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ketoconazole, an imidazole derivative which inhibits adrenal steroidogenesis, has been used with success for the metabolic control of Cushing's disease. Few data are available about the use of ketoconazole in the management of the ectopic ACTH syndrome. We have used ketoconazole in eight patients: four patients with Cushing's disease, two patients with overt and two with occult ectopic ACTH syndrome. Among patients with Cushing's disease, reversible hypoadrenalism occurred once. All had full clinical and biochemical regression of the disease for more than 6 months with 400-1200 mg ketoconazole per day. Patients with ectopic ACTH syndrome received 1200 mg ketoconazole per day for at least 2 months. Partial biochemical regression was observed in two and a secondary escape to adrenal blockade in two others. These findings further indicate that ketoconazole is a valuable tool for the metabolic control of Cushing's disease. On the contrary, in ectopic ACTH syndrome, this aim can be impossible to reach with ketoconazole although the reasons for its ineffectiveness remain to be determined. |
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Authors:
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A Tabarin; A Navarranne; J Guérin; J B Corcuff; M Parneix; P Roger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 34 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-04-25 Completed Date: 1991-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 63-9 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Hôpital Haut-lévèque, Bordeaux-Pessac, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ACTH Syndrome, Ectopic
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diagnosis,
drug therapy*,
metabolism Adult Cushing Syndrome / diagnosis, drug therapy*, metabolism Diagnosis, Differential Female Humans Hydrocortisone / blood, urine Ketoconazole / therapeutic use* Male |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 65277-42-1/Ketoconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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