| Use of intravenous tissue plasminogen activator in a 16-year-old patient with basilar occlusion. | |
MedLine Citation:
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PMID: 18827269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous tissue plasminogen activator (t-PA) is currently approved by the US Food and Drug Administration (FDA) for the treatment of ischemic stroke in patients > 18 years of age who present within 3 hours of stroke onset and meet certain criteria. We report a case of a 16-year-old, previously healthy female who presented with a basilar artery occlusion and pontine ischemic stroke. She was treated with intravenous t-PA approximately 4 hours after the onset of symptoms. The patient demonstrated a remarkable recovery 6 hours after onset of her symptoms and had minimal deficits on discharge from the hospital 1 week later. She was found to have a lupus anticoagulant and was heterozygous for the prothrombin gene G2010A mutation. These were likely contributing causes for her stroke. She was also homozygous for plasminogen activator inhibitor 1 (PAI-1) 4G/4G, which at present is a controversial stroke risk factor. |
Authors:
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Jason W Heil; Laurel Malinowski; Andrea Rinderknecht; Joseph P Broderick; David Franz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 23 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2009-01-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1049-53 Citation Subset: IM |
Affiliation:
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University of Cincinnati, Department of Neurology, Cincinnati, Ohio 45267-0525, USA. heiljw@email.uc.edu. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Basilar Artery / drug effects, pathology, physiopathology Blood Coagulation Disorders, Inherited / complications*, genetics*, physiopathology Brain Stem Infarctions / drug therapy, genetics, physiopathology Crohn Disease DNA Mutational Analysis Female Fibrinolytic Agents / administration & dosage Genetic Predisposition to Disease / genetics* Genetic Testing Genotype Humans Lupus Coagulation Inhibitor / blood, genetics Mutation / genetics Plasminogen Activator Inhibitor 1 / genetics Prothrombin / genetics Recovery of Function / drug effects Time Factors Tissue Plasminogen Activator / administration & dosage* Treatment Outcome Vertebrobasilar Insufficiency / drug therapy*, genetics*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Lupus Coagulation Inhibitor; 0/Plasminogen Activator Inhibitor 1; 9001-26-7/Prothrombin; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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